Phenylpropanoids and polyketides
Apexbio Technology LLC Epothilone B (EPO906, Patupilone)(Synonyms: Patupilone, EPO906, Epothilone B, (-)-Epothilone B, Epothilone B lactam), 100mg, CAS: 152044-54-7.
Epothilone B (EPO906 Patupilone CAS 152044-54-7) is a naturally occurring macrocyclic lactone initially isolated from the myxobacterium Sorangium cellulosum Sharing a mechanism of action similar to paclitaxel Epothilone B stabilizes microtubules thereby inhibiting cellular mitosis In vitro Epothilone B displays potent cytotoxic activity with an EC0 01 of approximately 1 8 nM Importantly Epothilone B effectively counters resistance mediated via P-glycoprotein which confers paclitaxel resistance and exhibits superior aqueous solubility compared to paclitaxel Research indicates Epothilone B treatment elevates intracellular free calcium and cytosolic cytochrome C in ovarian cancer SKOV-3 cells highlighting its utility as a research tool in cancer biology and chemotherapy resistance studies
Apexbio Technology LLC (5Z)-7-Oxozeaenol(Synonyms: (5Z)-7-Oxozeaenol, 7-Oxozeaenol, TAK1 inhibitor, MAPKKK inhibitor), 1mg, CAS: 253863-19-3.
(5Z)-7-Oxozeaenol (CAS 253863-19-3) is a naturally occurring resorcylic lactone obtained from fungal sources It functions as a selective inhibitor of transforming growth factor -activated kinase 1 (TAK-1) a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family In biochemical assays (5Z)-7-Oxozeaenol inhibits purified TAK-1 with an IC50 of approximately 8 1 nM exhibiting minimal activity against related MAPKKKs Cellular studies indicate irreversible blockade of IL-1-stimulated TAK-1 NF- B and JNK/p38 signaling pathways This molecule is useful in inflammation research as demonstrated by its suppression of IL-1-induced COX-2 production and attenuation of inflammatory responses in mouse models
Cayman Chemical 7-EthoxycoumarIn 250mg
A CYP450 substrate; undergoes O-deethylation by various CYP isoforms; has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea
Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid N-succinimidyl ester | 150321-92-9 | MFCD00467593 | ≥97.0% | 10 MG
7-Methoxycoumarin-3-carboxylic acid, succinimidyl ester is a coumarin-derived, amine-reactive fluorescent labeling reagent used to conjugate peptides and proteins for blue/UV fluorescence detection and intracellular imaging applications. The NHS ester enables efficient coupling to primary amines under mild conditions.
- Amine-reactive N-hydroxysuccinimide (NHS) ester for efficient conjugation.
- Strong blue fluorescence suitable for labeling peptides and proteins.
- Useful for synthesis of hydrophilic dye probes and intracellular viscosity measurements.
- Available in small research pack sizes for mg-scale conjugation experiments.
- Typical purity ≥97% (HPLC); consult the certificate of analysis for batch-specific data.
Cayman Chemical Coumarin Boronic Acid pinacol
A fluorescent probe for detection of peroxynitrite; a more soluble form of CBA; can be used to detect peroxynitrite, hypochlorous acid, and hydrogen peroxide; COH displays ex/em = 332/470 nm, respectively
Medchemexpress LLC Coumarin 343 | 55804-65-4 | MFCD00051335 | 95.7% | 285.30 g/mol | C16H15NO4 | 50 MG
Coumarin 343 (C343) is a hydrophilic fluorescent probe for micro water pools, microfluidic systems, and fluorescence-based assays. Supplied as a solid dye with high purity, it is suitable for analytical measurements and fluorescent labeling. The dye exhibits blue emission with a peak near 425 nm and measurable emission across the 425-550 nm range.
- Hydrophilic fluorescent probe for aqueous microenvironments.
- Emission peak near 425 nm for blue fluorescence detection.
- Emission range 425-550 nm provides a broad detection window.
- High purity (95.7%) suitable for analytical and labeling work.
- Supplied as a solid in small laboratory quantities for convenient handling.
Cayman Chemical 7-EthoxycoumarIn 1g
A CYP450 substrate; undergoes O-deethylation by various CYP isoforms; has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea
AdipoGen Coumarin 153
Chemical. CAS 53518-18-6. Formula C16H14NO2F3. Molecular Weight 309.28. Coumarin 153 is a well known polar laser dye. Spectral data lambdaem 532nm in ethanol Lasing peak 550nm, Lasing range 521-605nm. It can also be used as green phosphorescent dopant material for organic light-emitting diodes OLED.
Medchemexpress LLC Psoralen | 66-97-7 | 99.9% | 186.16 | 100 MG
Psoralen, also known as Ficusin, is a naturally occurring coumarin compound isolated from the seeds of Fructus Psoraleae. It is intended for research use only.
- Exhibits anti-cancer activity.
- Acts as an antioxidant.
- Demonstrates antidepressant properties.
- Possesses antibacterial effects.
- Shows antiviral activity.
Medchemexpress LLC 7-Methylcoumarin | 2445-83-2 | 1 ML
7-Methylcoumarin is a coumarin derivative known for its potent hepatoprotective and antioxidant properties. It acts as a mechanism-based inhibitor for CYP2A6 and has been shown to reduce liver damage markers and oxidative stress. It significantly reduces alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, while restoring total protein (TP) and albumin (TA) levels in serum.
- Acts as a mechanism-based inhibitor for human CYP2A6.
- Causes chromosomal aberrations in A. sativum Promeristem.
- Restores elevated levels of ALT and AST to near normal in rats.
- Restores antioxidant enzyme and TBARS levels.
- Restores serum TB and TP levels to near normal.
- Reduces hepatic lesions induced by CCl4.
eMolecules 6-Fluoro-4-hydroxycoumarin | 1G | Ships from Wood Dale, IL | Chem-Impex | 1994-13-4 | MFCD03094006 | MW: 180.13
Chem-Impex | 6-Fluoro-4-hydroxycoumarin | 1G | 1994-13-4 | MFCD07383035 | MW:177.22
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